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Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
FanDuel has made some tweaks to their scoring criteria for 2016. Check that out here. FanDuel is also only available to play for money in specific states. See their website for more details to see if FanDuel is playable for cash in your home state.
Pitcher
Jacob deGrom ($10,300) is the safest option in the early game. His velocity was finally back up to 2015 standards in his last start, averaging 95 mph on his fastball and generating a lot of strikeouts on high heat (I have a piece going up at SB Nation sister site AmazinAvenue at 10 am if you're interested in more detail). deGrom starts at home at Citi Field, a pitcher friendly park, where deGrom has posted a career ERA of 2.00 over 211 innings, not exactly a small sample size. The upside is limited because the Marlins don't strike out much vs RHP (19%) and they have an above average offense by wRC+, but deGrom's stuff looked so much better last time out against a potent Cubs lineup that he'll be a strong play for me today.
A cheaper, likely low owned option is Sonny Gray ($8,000) against the Twins. The Twins have a bottom third offense vs RHP by wRC+ at 86 and the 11th highest K% at 22.2%. Gray's hideous ERA of 5.42 will likely drive his ownership rate down. Gray brings plenty of risk with his poor season and would be a salary relief play for upside.
Hitting
Nationals vs Matt Garza
Since the start of 2015, Matt Garza is allowing a .294/.361/.480 line with a 5.14 ERA to lefties and a .292/.356/.458 line to righties with a 5.63 ERA. Daniel Murphy ($3,800) is hitting RHP to an elite 171 wRC+ this year with a .264 ISO. Bryce Harper ($4,100)'s numbers are down this year, but is still hitting RHP to a solid 130 wRC+ and .218 ISO.
Yoenis Cespedes ($3,500) is priced affordably and has been a top 5 hitter in the NL this year by wRC+ at 158. He faces below average LHP Justin Nicolino, has allowed a .293/.350/.471 line to RHB since the start of 2015. Cespedes is destroying LHP in a small sample this year, with a wRC+ over 200 and an ISO over .300.