Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
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Jacob deGrom ($10,300) is the safest option in the early game. His velocity was finally back up to 2015 standards in his last start, averaging 95 mph on his fastball and generating a lot of strikeouts on high heat (I have a piece going up at SB Nation sister site AmazinAvenue at 10 am if you're interested in more detail). deGrom starts at home at Citi Field, a pitcher friendly park, where deGrom has posted a career ERA of 2.00 over 211 innings, not exactly a small sample size. The upside is limited because the Marlins don't strike out much vs RHP (19%) and they have an above average offense by wRC+, but deGrom's stuff looked so much better last time out against a potent Cubs lineup that he'll be a strong play for me today.
A cheaper, likely low owned option is Sonny Gray ($8,000) against the Twins. The Twins have a bottom third offense vs RHP by wRC+ at 86 and the 11th highest K% at 22.2%. Gray's hideous ERA of 5.42 will likely drive his ownership rate down. Gray brings plenty of risk with his poor season and would be a salary relief play for upside.
Nationals vs Matt Garza
Since the start of 2015, Matt Garza is allowing a .294/.361/.480 line with a 5.14 ERA to lefties and a .292/.356/.458 line to righties with a 5.63 ERA. Daniel Murphy ($3,800) is hitting RHP to an elite 171 wRC+ this year with a .264 ISO. Bryce Harper ($4,100)'s numbers are down this year, but is still hitting RHP to a solid 130 wRC+ and .218 ISO.
Yoenis Cespedes ($3,500) is priced affordably and has been a top 5 hitter in the NL this year by wRC+ at 158. He faces below average LHP Justin Nicolino, has allowed a .293/.350/.471 line to RHB since the start of 2015. Cespedes is destroying LHP in a small sample this year, with a wRC+ over 200 and an ISO over .300.