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Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
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Hitting
The Padres get a park upgrade in Cincinnati and face a lefty with below average peripherals. The biggest lefty masher on the Padres this year is Matt Kemp ($3,800), who has hit LHP to a 196 wRC+ and .400 ISO, and owns a 153 wRC+ and .277 ISO over a larger sample dating back to the start of last season. The Reds also back up their starters with a terrible bullpen, which ranks last in baseball with a 6.03 ERA and 5.90 FIP.
The Diamondbacks face one of the least productive lefties in baseball this year in Coors Field. Jorge de la Rosa pitches for the Rockies, who has an ERA over 7 and FIP over 6. Paul Goldschmidt ($4,900) has hit LHP to a 191 wRC+ and .243 ISO since the start of 2015. Teammate Wellington Castillo ($3,600) has hit LHP to a 149 wRC+ and .304 ISO since the start of last year, with Yasmany Tomas at a 137 wRC+ and .250 ISO.
Pitching
No top tier aces go in the early game, which leaves more salary for hitting. The safest option for me is John Lackey ($9,900) against the Marlins. The Marlins don't strike out much vs RHP and have a mediocre team wRC+ of 97 vs RHP, so there isn't exactly a high ceiling for strikeouts, but Lackey has dramatically improved his K% this year, up to 27%, and the Cubs offense gets to face Paul Clemens, a significantly below average pitcher. Lackey looks to be a good bet to be in position for the win and pitch reasonably well.