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Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
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Early
The pitcher I will most likely use in the early game is Johnny Cueto ($10,700) vs the Brewers. The Brewers have the highest strikeout rate vs RHP at 26% and a bottom third wRC+ of 90. The Brewers also get a park downgrade in San Francisco, a very pitcher friendly park. Cueto has a 2.16 ERA, 2.55 FIP and 22% strikeout rate, and looks like a good bet to pitch well, rack up a strong strikeout total, and be in position for the win.
Late
In the late game, Marco Estrada ($8,600) faces a poor Phillies offense that ranks 3rd worst by wRC+ vs RHP at 76 and has a below average strikeout rate of 22.3%. Estrada has a 22% strikeout rate and is a pitcher who skillfully beats some of his peripherals like FIP because of how many harmless fly balls he generates. Estrada has a 49% fly ball rate, and 18% of them are infield pop ups. He also limits line drives to 15%, significantly above average. Estrada won't run a .189 BABIP all season, because that is incredibly difficult to do, but his profile suggests he is skillfully a low BABIP guy based on the trajectories he allows with his high spin fastball and change up combo. Hitters might figure him out at some point down the road, but he's been fantastic for 260+ innings now dating back to the start of last season. The below average Jeremy Hellickson opposes Estrada, which makes run support look good.