Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
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The top pitching option for me today is between Jon Lester ($11,000) and Jose Fernandez ($10,800). Lester faces a Padres offense that has the second highest strikeout rate vs LHP at 26.2% and has a bottom half wRC+ at 94. Lester has a 25% strikeout rate and will be a good bet to get a lot of run support from the Cubs lineup. The Cubs have had a historically good run differential to this point of +102, backed by their 116 team wRC+, which is second only to the Red Sox. Lester looks to be a good bet to pitch well and get the win.
Fernandez faces a similarly performing Brewers lineup in Miami; they have the third highest strikeout rate vs RHP at 25.4% and are 15th in wRC+ at 94. Fernandez has an outstanding 33% strikeout rate, but hasn't been getting deep into games and has been underperforming by his standards to this point. Lester is probably the safer option for me, but Fernandez has a higher ceiling because of his ability to rack up double digit K's with mid 90s heat and a ridiculous curveball. Fernandez has also historically pitched much better at home in pitcher friendly Marlins Park, with a 1.71 ERA at home vs a 3.77 road ERA. Marlins Park's outfield walls have been adjusted for this season, but the park still appears to play pitcher friendly from what I've seen.
For hitters, the Diamondbacks play the Rockies in Coors. Rubby de la Rosa pitches for the DBacks; he's allowed a .300/.375/.543 slash to lefties since the start of last year, so getting a few Rockies lefties in against him is probably a good idea. LHB Carlos Gonzalez ($3,900) is not overly expensive and has hit RHP to a 146 wRC+ and .307 ISO since the start of last year. LHB Ben Paulsen ($2,900) is one of the cheaper Coors bats; he has a 99 wRC+ and .193 ISO vs RHP since the start of last year. On the Diamondbacks side, David Peralta ($4,000) has a 142 wRC+ and .218 ISO vs RHP since the start of last year, although he sat out yesterday with a barking forearm after being hit by a pitch the day before.
The A's get a park upgrade in Boston and face the erratic Clay Buccholz, who has a 5.71 ERA and 4.98 FIP this year and tends to be very boom or bust. Catcher Stephen Vogt ($2,700) is usually one of the better plays at catcher against mediocre to poor RHP; he's hit RHP to a 111 wRC+ and .177 ISO since the start of last year, well above the MLB average wRC+ for catchers, which is 85.
Other options a fantasy owner can consider are David Wright ($3,300) vs Scott Kazmir. Wright has destroyed lefties throughout his career and is actually hitting for power this year despite his back condition, running a .213 ISO. Wright has 112 ABs, which is getting close to the ISO stabilization point of about 160 ABs. Kazmir has not pitched will since the second half of last season and his struggles have carried over into 2016 as he's batted a problem on his throwing hand.