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Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
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Early: pitching
A few good pitchers have some tough matchups. Steven Matz ($9,900) is awesome, but the Nationals have hit LHP really well. They have the 3rd best offense vs LHP with a 124 wRC+ and the highest team ISO at .215. Jake Arrieta ($12,300) is a monster, but he faces the Cardinals, who have the second highest wRC+ vs RHP at 127 with an ISO of .213. Carlos Martinez ($8,500) faces the Cubs, who have the 6th best offense vs RHP with a 111 wRC+ and .170 ISO. Aaron Nola ($8,900) faces the Tigers, who have the 3rd best offense vs RHP with a 117 wRC+ and .188 ISO.
The worst offenses in the early game are the Phillies and Padres. The Phillies play in Detroit against the Tigers. Anibal Sanchez ($6,800) is cheap, but cheap for a reason: he has an ugly 6.23 ERA and 5.47 FIP. It is a similar situation in SF, where the Padres face Jake Peavy and his 8.21 ERA/5.13 FIP.
Jose Quintana ($9,300) is my choice, and appears to have the strongest matchup. The Indians have a bottom third wRC+ of 85 vs LHP with an ISO of .117. Quintana has a 1.98 ERA and 2.08 FIP. The downside is that Corey Kluber opposes him, although Kluber hasn't prevented runs as well this year.
Late: hitting
The Rays have the #1 offense vs LHP with a 127 wRC+ and .214 ISO. They face the below average Justin Nicolino, who has a 4.3 ERA and 5.11 FIP, with a minuscule strikeout rate of 5%. The best value from the Rays offense based on pricing is probably Brandon Guyer ($3,400), who has a 155 wRC+ and .201 ISO vs LHP since the start of last year. Evan Longoria ($4,000) is pricey, but has hit LHP to a 148 wRC+ and .222 ISO since the start of last year. Steve Souza ($3,200) has hit LHP to a 128 wRC+ and .211 ISO in that time frame. Steve Pearce ($3,600) has destroyed LHP in a small sample this year to a 279 wRC+ and .447 ISO, and has a 123 wRC+ and .233 ISO since the start of last year.