Reminder: Always double check the lineup card before rosters lock to make sure that a player you've chosen to roster is playing that day, and check the weather to make sure your players won't get rained out of their game.
Danny Salazar and his high K rate looks like the best choice at first, but I'm personally going in a different direction for a few reasons. I suspect he will be hugely owned across the board, and the Angels have upgraded their already top 10 offense vs RHP recently by adding LHBs David Murphy and David DeJesus, neither of which are All Stars but are both competent MLB hitters vs RHP.
If I play the early game, my choice will likely be Erasmo Ramirez instead. Ramirez has good peripherals in addition to good run prevention; his 12.6% swinging strike% is well above average (it's actually higher than Salazar's, if you can believe that). His 48% GB%, 3.61 ERA, and 3.67 FIP are also above average. Ramirez faces a White Sox offense that is 11th highest in K% vs RHP at 20.5% and has a bottom third wRC+ of 90. I also suspect Ramirez will be low owned.
If a fantasy owner has a strong feeling about starting Salazar, go ahead, but that's my thinking for the early pitching game.
Mariners RHB vs Chris Rusin
Some Mariners hitters will get the platoon split edge in Coors Field, and two of them are priced incredibly low. OF Mark Trumbo is priced at the minimum ($2,200) and has hit LHP to a 111 wRC+/.201 ISO over 192 PA the last 2 seaons. OF Nelson Cruz ($5,600) will cost a fortune, but low priced pitching top to bottom allows a fantasy owner to spend here, and he has destroyed LHP to a 194 wRC+ and .292 ISO over his last 263 PA vs LHP dating back to the start of 2014. C Jesus Montero ($2,400) is an enigma, but has re-dedicated himself to the sport; he finally began taking his condition seriously and hit AAA pitching to a 148 wRC+ this year. Rusin has given up a .301/.351/.460 line to RHB in 2015 and combines that with a 4.32 FIP.
Scott Kazmir ($9,500) vs Texas Rangers
Kazmir against a lefty heavy Rangers offense is a good mix of production and salary relief. Key hitters Rougned Odor, Prince Fielder, Mitch Moreland, Shin Coo Choo and Josh Hamilton all bat lefty, and the Rangers on the year have a 23% K% vs LHP, 7th highest, with the 6th worst wRC+ vs LHP at 84. Kazmir's non elite price also provides salary relief to help improve hitting slots.
OF- Bryce Harper ($4,400) vs Rubby de la Rosa
Harper has hit RHP to an insane 211 wRC+ and .360 ISO and faces a RHP who has given up a .309/.365/.583 slash vs LHB with a 6.44 FIP. Harper's run scoring environment in his lineup also figures to strongly improve with the return of Rendon, Zimmerman and Werth, who are now back in the lineup after missing chunks of the season due to injury.
SS- Jhonny Peralta ($3,000) vs David Holmberg
Peralta gets a park upgrade in Cincinnati and faces a LHP projected by ZiPS to have an ERA over 5 the rest of the season. Peralta is one of the game's best lefty hitters, hitting them to a 147 wRC+ in 400 PA since 2013, 10th best, and combines it with a strong .232 ISO.
Follow me on Twitter at @TimFinn521, I usually tweet out more good options as lineups are released.