Carson Palmer, ARI vs. BAL - Palmer is averaging 323.3 passing yards per game in home games and two touchdowns per game. He has yet attempted fewer than 32 pass attempts in a home game. This week he plays at home and has a favorable matchup against the Ravens. Quarterbacks are averaging 8.24 passing yards per attempt and 305 passing yards per game against the Ravens. They've allowed 11 touchdowns and have surrendered multiple touchdowns in four of their six games. He should continue his streak of 300+ passing yards in every home game against the Ravens this week.
Philip Rivers, SD vs. OAK
Eli Manning, NYG vs. DAL
Drew Brees, NO at NO
Ryan Tannehill, MIA vs. HOU
Sleeper Alert: Ryan Fitzpatrick, NYJ at NE
Sam Bradford, PHI at. CAR - After two solid outings, Bradford had a poor performance against the Giants last week. He threw for 280 yards, a touchdowns and three interceptions. He has a tough task ahead of him as he faces a stingy Panthers defense. Opposing quarterbacks have thrown five touchdowns and eight interceptions against the Panthers. They're allowing 253 passing yards and just 13.2 fantasy points per game. They have only allowed one multiple touchdown game this season. In home games, the Panthers have only allowed one passing touchdown. Bradford has scored fewer than 13 fantasy points three times this season. It's tough to trust him on the road in a tough matchup after he's be so hit or miss this year.
Colin Kaepernick, SF vs. SEA
Joe Flacco, BAL at ARI
Josh McCown, CLE at STL
Derek Carr, OAK at SD
Bust Alert: Matthew Stafford, DET vs. MIN
Todd Gurley, STL vs. CLE - Gurley has rushed for over 140 yards in the last two games. He's averaging 6.22 yards per carry in those games and has two 50+ yard carries. In that span, he has also been in 63 percent or more of the team's offensive snaps. His success has come against two respectable defenses and this week he has the Browns on deck who struggle to stop the run. Opposing backs average 131.5 rushing yards per game, 4.5 receptions per game, and 54 receiving yards per game against the Browns. The Browns have actually yielded the most rushing yards this season. He's living up to expectations and should be fired up in your lineups this week.
Lamar Miller, MIA vs. HOU
LeSean McCoy, BUF vs. JAC
Latavius Murray, OAK at SD
Mark Ingram, NO at IND
Sleeper alert: Christine Michael, DAL at NYG
Melvin Gordon, SD vs. OAK - The Chargers benched Gordon in the second half of last week's game after he fumbled the ball twice. This week he has a favorable matchup against the Raiders, but it's tough to have any faith in him after what happened in the last game. Gordon has yet scored a touchdown or reached double digit fantasy points in standard formats this season. He's averaging 3.8 yards per carry and only receives 20 percent of the team's red zone rushes. He's also been out snapped by Danny Woodhead. If there's a back you want in your lineup from the Chargers this week it's Woodhead. The offense runs smoother when he's in the game and he's been far more efficient than Gordon. In Week 4, Gordon had a great matchup against the Browns, one of the worst run defenses in the league, but he had a disappointing outing. I'd wait for better production before plugging him in your lineups.
Joseph Randle, DAL at NYG
Ameer Abdullah, DET vs. MIN
LeGarrette Blount, NE vs. NYJ
Charcandrick West, KC vs. PIT
Bust Alert: Carlos Hyde, SF vs. SEA
T.Y. Hilton, IND vs. NO - The Colts game has the highest over/under of the week and the Colts implied points scored is 28.5. That means that we should be expecting a shootout. Hilton is averaging 9.8 targets per game, but has been targeted 31 times in the last three games. He has caught five or more passes and eclipsed 65 receiving yards in each of the last three games, and finally scored his first touchdown of the season. The Saints are surrendering 153 receiving yards, 18.8 fantasy points per game, and 15 yards per reception. They've allowed five touchdowns to opposing receivers and have allowed a touchdown in three consecutive games. Hilton has received the most targets of all receivers in the Colts and should continue to see plenty of looks this week. With Andrew Luck looking like his old self, Hilton could be in for one of his big games.
Mike Evans, TB at WAS
John Brown & Larry Fitzgerald, ARI vs. BAL
Eric Decker, NYJ at NE
Jarvis Landry, MIA vs. HOU
Sleeper Alert: Stefon Diggs, MIN at DET
Anquan Boldin, SF vs. SEA - Boldin has now gone over 100 receiving yards in consecutive games, but has a tough matchup at home against the Seahawks. Receivers are averaging 120.7 yards per game and 11.5 yards per reception against Seattle's defense. The Seahawks have surrendered just one receiving touchdown this season and have held opposing receivers under 110 yards in four of their six games. Needless to say, they are as stingy as it gets. In fact, they have not allowed more than 106 receiving yards in a road game this season. Boldin has not scored a touchdown against the Seahawks since 2004. He has eclipsed 25 receiving yards just once in his last five regular season games against them. It's tough to expect the same production you've been getting from Boldin in the last two weeks this week. You might be better off seeking an alternative option and keep Boldin on the bench.
Jordan Matthews, PHI at CAR
Kendall Wright, TEN vs. ATL
Brandin Cooks, NO at IND
Michael Crabtree, OAK at SD
Bust Alert: Allen Robinson, JAC vs. BUF
Owen Daniels, DEN at OAK
Antonio Gates, SD vs. OAK
Kyle Rudolph, MIN at DET
Heath Miller, PIT at KC
Larry Donnell, NYG vs. DAL
Zach Ertz, PHI at CAR
Seattle Seahawks at San Francisco 49ers
St. Louis Rams vs. Cleveland Browns
New York Jets at New England Patriots
Baltimore Ravens at Arizona Cardinals