Eli Manning, NYG at PHI - Eli has put together a nice three game stretch with eight touchdowns and just one interception. In that span, the team is 3-0. It certainly appears that this offense is much more in sync. This week he faces the Eagles that allow the second most fantasy points to opposing quarterbacks (21.2). The Eagles have allowed the most passing touchdowns this season (13) and they are allowing 274 passing yards per game. This is a great matchup for Manning to continue his streak of good performances. If you own Drew Brees and are looking for a bye week replacement, Eli Manning is a great option.
Ben Roethlisberger, PIT at CLE
Jay Cutler, CHI at ATL
Colin Kaepernick, SF at STL
Matt Ryan, ATL vs. CHI
Sleeper Alert: Ryan Tannenhill, MIA vs. GB
Tony Romo, DAL at SEA - Romo finally threw for 300+ yards in a game this season last week against the Texans. This week however, he heads to Seattle, where not many quarterbacks find success. The Seahawks have hosted the Packers and Broncos this season. Both teams have arguably some of the best QB's in the league. Against Aaron Rodgers, the Seahawks gave up 189 yards and one touchdown, while also intercepting one pass; and versus Peyton Manning, they gave up 303 yards and two touchdowns, along with an interception. Keep in mind, the two touchdowns came in the fourth quarter. Bottom line, the Seahawks play superb defense at home. Romo is known to have multi interception games. In fact, he hasn't had one since Week 1. He's due.
Kirk Cousins, WAS at ARI
Cam Newton, CAR at CIN
Teddy Bridgewater, MIN vs. DET
Mike Glennon, TB vs. BAL
Bust Alert: Nick Foles, PHI vs. NYG
Eddie Lacy, GB at MIA - Lacy finally had a big game in Week 5. He rushed for 105 yards and two touchdowns, and caught three passes for 27 yards. Lacy should carry the momentum over into Week 6 against a Dolphins' defense that's allowing 19.8 fantasy points per game to running backs. They are allowing 107.3 yards per game and have allowed three rushing touchdowns in four games. Prior to last week's game, Lacy was struggling. He hadn't rushed for over 48 yards in a single game. Last week's performance is exactly what Lacy needed to break out of the funk.
Andre Williams, NYG at PHI
Frank Gore, SF at STL
Justin Forsett, BAL at TB
Andre Ellington, ARI vs. WAS
Sleeper alert: Branden Oliver, SD at OAK
Stevan Ridley, NE at BUF - Ridley went from a five carries for 28 yards performance in Week 4, to a 27 carries for 113 yards and a touchdown in Week 5. The problem here is the lack of consistency. It's hard to trust any running back in New England. The matchup doesn't help either. The Bills are one of two teams in the NFL that have yet allowed a rushing touchdown this season. They are also holding running backs to just 71 rushing yards per game and are allowing the second fewest fantasy points per games (9.8). Ridley has two games over 100 rushing yards this season, but three games where he rushed for 54 yards or less. He also has two games with over 20 carries, but three games with a combined 32 carries. Ridley is very hit or miss and has a tough matchup this upcoming week. There's not enough upside to overcome all the negatives.
Darren McFadden, OAK vs. SD
Ronnie Hillman, DEN at NYJ
Trent Richardson, IND at HOU
Bust Alert: Zac Stacy, STL vs. SF
Emmanuel Sanders, DEN at NYJ - Sanders has posted three consecutive 100+ receiving yards games. It's very unlikely that he will slow down this week. The Jets defense is allowing 260.6 receiving yards per game and has allowed the second most receiving touchdowns (12). Wide receivers are averaging 23.6 fantasy points per game against the Jets. Sanders is having a great season so far, he's caught 32 passes for 435 yards in four games. The only thing that he's been unable to do is get in the end zone. That can very possibly change this weekend. With Montee Ball out, the Broncos could very well rely mainly on Manning's arm this week. The Jets secondary is vulnerable and will likely get picked apart by Manning. Look for Sander's streak of 100+ receiving yards in a game to continue this week.
Golden Tate, DET at MIN
Percy Harvin, SEA vs. DET
Michael Crabtree, SF at STL
Keenan Allen, SD at OAK
Sleeper Alert: Mohamed Sanu, CIN vs. CAR
Cordarrelle Patterson, MIN vs. DET- After a promising start to the season, Patterson has been a disappointment. After a 128 total yards game in Week 1, he has 156 total yards in the last four games combined. This week he takes on the Lions defense that has been surprisingly solid this season. They are second in the league with 17 sacks, have four interceptions, and have forced seven fumbles. The Lions have allowed just two receiving touchdowns this season. They kept the Packers and Giants wide receivers out of the end zone. They are allowing just 13.6 fantasy points to receivers. This is a matchup that fantasy owners should avoid, especially with a receiver that continues to struggle. Until he's more involved in the play calling, it'll be hard to trust Patterson in your starting lineup.
Larry Fitzgerald, ARI vs. WAS
Terrence Williams, DAL at SEA
Eric Decker, NYJ vs. DEN
Sammy Watkins, BUF vs. NE
Bust Alert: Pierre Garcon, WAS at ARI
Larry Donnell, NYG at PHI
Delanie Walker, TEN vs. JAC
Greg Olsen, CAR at CIN
Jared Cook, STL vs. SF
Heath Miller, PIT at CLE
Jason Witten, DAL at SEA
Detroit Lions at Minnesota Vikings
Houston Texans vs. Indianapolis Colts
New York Jets vs. Denver Broncos