Defense to start: San Francisco 49ers - The Niner defense is absolutely dominating their NFC West rivals. They are allowing only 8 points/game this season in their first three games against Seattle, St. Louis and Arizona. They held Arizona to only 229 yards on Nov. 20 but the Cardinals were playing without Kevin Kolb. I don't think he will make much difference in the rematch.
Defenses to avoid: Oakland Raiders - Oakland is taking on Green Bay at Lambeau. This season the Pack have been averaging 35 points/game, to put that in perspective, New England averaged 36.8 in their 2007 undefeated regular season. Oakland has been giving up the 6th most points. Leave Oakland on the bench.
Indianapolis Colts - Indianapolis is giving up the most points in the league, 29.8. This week they face a Baltimore team that is really establishing the run, which is another area that the Colts have struggled with. They also are at the bottom of the league in interceptions with 5.
All 32 defenses are ranked following the jump.
| Team | Opp. |
| 1. San Francisco 49ers | ARZ |
| 2. Baltimore Ravens | IND |
| 3. Seattle Seahawks | STL |
| 4. Pittsburgh Steelers | CLE |
| 5. New York Jets | KC |
| 6. Houston Texans | CIN |
| 7. Denver Broncos | CHI |
| 8. Green Bay Packers | OAK |
| 9. Miami Dolphins | PHI |
| 10. New England Patriots | WAS |
| 11. Detroit Lions | MIN |
| 12. Chicago Bears | DEN |
| 13. Tampa Bay Buccaneers | JAX |
| 14. St. Louis Rams | SEA |
| 15. New York Giants | DAL |
| 16. Philadelphia Eagles | MIA |
| 17. Jacksonville Jaguars | TB |
| 18. Dallas Cowboys | NYG |
| 19. Kansas City Chiefs | NYJ |
| 20. Cincinnati Bengals | HOU |
| 21. Atlanta Falcons | CAR |
| 22. San Diego Chargers | BUF |
| 23. New Orleans Saints | TEN |
| 24. Minnesota Vikings | DET |
| 25. Arizona Cardinals | SF |
| 26. Buffalo Bills | SD |
| 27. Carolina Panthers | ATL |
| 28. Cleveland Browns | PIT |
| 29. Washington Redskins | NE |
| 30. Oakland Raiders | GB |
| 31. Tennessee Titans | NO |
| 32. Indianapolis Colts | BAL |