All 26 defenses playing this weekend are ranked following the jump.
Defenses to start: Baltimore Ravens and Dallas Cowboys - These are strong defenses playing some very weak offenses. There will be a ton of sacks and turnovers to benefit from.
Defenses to avoid: Minnesota Vikings, Kansas City Chiefs and Indianapolis Colts - I think these defenses will be on the field for much of their games. They have playmakers but the opposition's offenses will just dominate them.
| Team | Opp. |
| 1. Baltimore Ravens | JAX |
| 2. Dallas Cowboys | STL |
| 3. Pittsburgh Steelers | ARZ |
| 4. Green Bay Packers | MIN |
| 5. San Diego Chargers | NYJ |
| 6. Tampa Bay Buccaneers | CHI |
| 7. Cleveland Browns | SEA |
| 8. Detroit Lions | ATL |
| 9. New York Jets | SD |
| 10. Chicago Bears | TB |
| 11. Washington Redskins | CAR |
| 12. Denver Broncos | MIA |
| 13. New Orleans Saints | IND |
| 14. Tennessee Titans | HOU |
| 15. Carolina Panthers | WAS |
| 16. Seattle Seahawks | CLE |
| 17. Oakland Raiders | KC |
| 18. Houston Texans | TEN |
| 19. Miami Dolphins | DEN |
| 20. Arizona Cardinals | PIT |
| 21. Jacksonville Jaguars | BAL |
| 22. Atlanta Falcons | DET |
| 23. Kansas City Chiefs | OAK |
| 24. Minnesota Vikings | GB |
| 25. Indianapolis Colts | NO |
| 26. St. Louis Rams | DAL |