Listed below are those players from Baseball America's Top 100 prospects who are not slated to arrive in the majors until the next decade. For very deep keeper leagues, there are likely several players from this list who will find themselves occupying reserve slots in your league.
| TOP 100 RK | PROSPECT | TM | POS | ETA |
| 18 | Mike Moustakas | KC | SS | 2010 |
| 19 | Elvis Andrus | TEX | SS | 2010 |
| 20 | Fernando Martinez | NYM | OF | 2010 |
| 21 | Rick Porcello | DET | RHP | 2010 |
| 28 | Jason Heyward | ATL | OF | 2010 |
| 35 | Deolis Guerra | MIN | RHP | 2010 |
| 37 | Jose Tabata | NYY | OF | 2010 |
| 40 | Lars Anderson | BOS | 1B | 2010 |
| 41 | Austim Jackson | NYY | OF | 2010 |
| 46 | Jarrod Parker | AZ | RHP | 2010 |
| 57 | Daniel Cortes | KC | RHP | 2010 |
| 59 | Desmond Jennings | TB | OF | 2010 |
| 67 | Chris Tillman | BAL | RHP | 2010 |
| 74 | Dexter Fowler | COL | OF | 2010 |
| 76 | Adrian Cardenas | PHI | 2B | 2010 |
| 79 | Hank Conger | LAA | C | 2010 |
| 81 | Jordan Walden | LAA | RHP | 2010 |
| 84 | Tim Alderson | SF | RHP | 2010 |
| 90 | Joe Savery | PHI | LHP | 2010 |
| 92 | Gorkys Hernandez | ATL | OF | 2010 |
| 95 | Hector Gomez | COL | SS | 2010 |
| 96 | Ryan Kalish | BOS | OF | 2010 |
| 100 | Drew Stubbs | CIN | OF | 2010 |
| 33 | Angel Villalona | SF | 1B | 2011 |
| 43 | Josh Vitters | CHC | 3B | 2011 |
| 62 | Carlos Truinfel | SEA | SS | 2011 |
| 83 | Phillippe Aumont | SEA | RHP | 2011 |
| 93 | Neftali Perez | TEX | RHP | 2011 |